Articles
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Praziquantel is given on and off label and by mouth or injection to treat various internal parasites in cats, dogs, small mammals, birds, reptiles, and large animals. Do not use in pets that are allergic to it, in puppies less than 3 weeks old, or kittens less than 6 weeks old.
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Prednisone/prednisolone is given by mouth or injection and is used on and off label to treat Addison’s disease, inflammatory conditions, neoplasia (cancer), and immune-mediated diseases. Give this medication as directed by your veterinarian.
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Probiotics are given by mouth and are used over the counter to treat gastrointestinal upset. Give as directed by your veterinarian. Side effects are rare but may include gas or mild discomfort. Do not use in pets that are very sick and immunocompromised, or in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.
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Procainamide (brand names Pronestyl®, Biocoryl®, Procan®, Procanbid®) is an antiarrhythmic drug used off label (extra label) in dogs and horses to treat abnormal heart rhythms such as atrial fibrillation, ventricular premature complexes, and ventricular tachycardia.
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Propantheline bromide (brand name: Pro-Banthine®) is an antimuscarinic used off label to treat muscle spasms, incontinence, diarrhea, and sometimes slow heart rate. In horses, it is used to relax the muscles for procedures in the colon.
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Propranolol (brand names Inderal®, Detensol®, Hemangeol®, Innopran®) is a beta-blocker used off label (extra label) to treat abnormal heart rhythms (arrhythmias) in cats, dogs, ferrets, and horses. It has also been used short-term to treat hypertension caused by thyrotoxicosis or pheochromocytoma. It is given by mouth or injection.
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Pyrimethamine + sulfadiazine (ReBalance®) is a drug used for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona in horses. It may be used off label to treat neosporosis in dogs or toxoplasmosis in cats.
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Rifampin is commonly used off label to treat infections in horses, and occasionally in dogs and cats. It is usually given by mouth in the form of a capsule or compounded liquid. The most common side effects are vomiting, diarrhea, or reduced appetite. Liver dysfunction is possible. A change in the color of urine, tears, and saliva to a red/orange color is expected but may stain fabrics. Use with caution in pets that have pre-existing liver disease, are pregnant, are elderly, or are lactating. If a negative reaction occurs, call your veterinary office.
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Rifaximin is an antibiotic drug used to treat chronic diarrhea in dogs. It may also be effective in reducing neurological signs associated with liver disease in dogs and cats. It is used to treat and prevent mastitis in cows, and to treat endometritis in cows and horses.
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Ophthalmic autologous serum is a blood-derived product used to treat corneal ulcers in animals. Ophthalmic autologous serum is part of the blood and is collected directly from the patient. It is in liquid form.

